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What is a Metabolic Modulator?

Jason Hughes
Published by Jason Hughes
Fact checked by Markus Oliver, BHSc FACT CHECKED
Last updated: July 3, 2022

When looking to achieve peak weight loss, the most touted and sustainably beneficial method for doing so involves proper exercise and a healthy diet. For some, this may not be enough. For those that are suffering from cardiac and somatic issues, there are a number of prescribed medicines that can do the trick. Traditionally, obesity and cardiovascular issues are solved by methods such as blood thinners and anti-inflammatory medication. Further, those who want to push the boundaries of their bodies and reach optimal performance may wish to use certain drugs that enhance their athletic ability.

In this article, we will explore Metabolic Modulators: a new class of drug that increases the ability of your body to burn fat, without increasing the composition or glucose levels in the blood. We will first define what a metabolic modulator is, what the benefits of metabolic modulators are, and ultimately, the side effects and questions associated with their use.

What is a Metabolic Modulator?

A metabolic modulator can be anything that changes the speed at which the metabolism works throughout the body. To date, the only metabolic modulators scientists are looking for are those that speed up the metabolism and increase the proper utilization of the glucose levels within the body instead of the free fatty acids.

Metabolic modulators usually work by changing the way receptors in the body relay and absorb different messages.

 

Metabolic modulators can give the cells a set of completely new instructions that focus on changing the way the metabolic burn rate works throughout the body.

For example, Cardarine is a metabolic modulator that stimulates the PPAR agonists within the cells. Compounds such as Cardarine tell the cells to act upon the energy within the cells to increase the amount that is expended. Further, it burns the available ATP (energy) in a better way - by increasing the oxygenation levels that are delivered both to the somatic and cardiac cells. There are also drugs that contain endogenous metabolism modulators (EMM) that are useful for such things as heart failure and immune diseases.

In short, metabolic modulators fill a gap in the body that cannot otherwise process sustained caloric intake. This may be a result of a disease, an unhealthy lifestyle, or a combination of the two.

What are the Benefits of Metabolic Modulators?

Metabolic modulators are not just one substance. They can be any different things, down to the food you eat. This can include amino acids, bile acids, and hormones. For example, coffee can be considered a mild metabolic modulator. Coffee contains caffeine, which helps both with appetite suppression and increases the metabolic rate at which the body burns available energy. This is why caffeine is common in most pre-workout supplements, as it gives both the strength and the endurance for effective results in the gym. Here are the main benefits of metabolic modulators:

Reduces weight and fat: The most important reason that metabolic modulators are being researched is for their use in "slimming down" patients. One way this can be used is to fight the ever-increasing obesity levels in the world, and throughout the US in general. This is done by increasing the body's ability to burn the glucose available in the cells, which is much more effective than the fatty acids. This will naturally get rid of unwanted fat over time, provided caloric intake remains the same or lower. This can also be used for those who have inordinate weight gain due to mental disorders and diseases.

Helps control blood sugar and blood fat levels: Your muscles and somatic cells aren't the only ones who have a caloric burn rate. Your cardiac metabolic rate is used to control the cells within the blood and cardiovascular system. This means that the assistance is twofold. First, metabolic modulators can increase the rate at which the body burns glucose, meaning that blood sugar levels can go down drastically with prolonged use. This is great for those who are suffering from fatty liver, diabetes, and heart disease. Second, fatty acids within the blood and cholesterol levels are also brought down, which decreases blood pressure and can help regulate cholesterol levels.

Works as an anti-inflammatory: Inflammation as a result of excess fat or a weak immune system can be treated with metabolic modulators. The increased metabolic burn will reduce fat, swelling, and inflammation - while the excess energy speeds up the body's immune response.

Increases muscle development: Increasing the energy levels available by an accelerated metabolism helps the muscles and tissues to have more resources available to achieve peak athletic performance. This means that there is a notable positive shift in speed, endurance, workload, and strength.

What are the Side Effects of Metabolic Modulators?

An increased metabolism may lead to great benefits but should only be done under the advisement of a healthcare or medical professional. Side effects from prolonged use can include:

  • Fatigue
  • Rashes
  • Abdominal pain
  • Headaches
  • Dizziness
  • Unquellable appetite

In severe cases:

  • At the risk of thrombosis
  • At the risk of a weakened endocrine system
  • At the risk of certain cancers

FAQs

What is metabolism?

Metabolism is the process in which your body converts calories into available energy. It is a complex process that involves hormones, acids, and other substances within the body breaking down food and drink and forming them into the necessary materials to carry out other functions, such as energy, building blocks for cells, and repairing injury.

How can you naturally increase your metabolism?

Metabolism can be increased naturally both by the foods you eat and the type of exercise that you do. For example, HIIT training is proven to increase metabolic burn during and up to 24 hours after a workout. Certain foods and drinks, such as coffee, caffeinated tea, beans, ginger, spicy foods, and foods heavy in protein all help to increase the metabolic burn.

How can I tell if my metabolism is too slow?

The easiest way to tell if your metabolism is slowing down is to notice weight gain. If you have always stuck to a healthy diet and exercise regimen, yet you are still gaining weight over time - this is a surefire sign that your metabolism has become slower. Other signs include ongoing fatigue, continuous headache despite water intake, and brittle nails.


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