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What Are The Side Effects of Using a Metabolic Modulator?

Jason Hughes
Published by Jason Hughes
Fact checked by Markus Oliver, BHSc FACT CHECKED
Last updated: June 15, 2022

When looking to push the boundaries of athletics, bodybuilding, and performance and to achieve the body and weight goals, some in the fitness industry look towards certain substances that fall outside of the natural supplement world to drastically increase their development, both in a shorter period and in terms of quality gains. One such substance is Cardarine, a metabolic modulator that is often confused with another class of chemicals, called SARMs. Cardarine is currently a banned substance in terms of retail sales but is available to purchase in certain areas for research or lab use.

In this article, we will aim to define what a metabolic modulator is, how it differs from SARMs, and weigh the pros and cons of Cardarine as a substance in conjunction with its effects on the body. Finally, we'll cut the guesswork and show where it is available for purchase.

What is a Metabolic Modulator?

Metabolic modulators are new and are not yet relatively well-researched or approved for public use. They are a separate class of drugs and were initially tested on animals in the early 2000s. Since there were adverse effects, the project was scrapped - but has since resurfaced. Metabolic modulators are looking to improve the management of certain circulatory, respiratory and heart-related issues and failure by increasing (or decreasing) the cardiac metabolism without changing the dynamics of the blood cells, arterial walls, or the way the circulatory system operates on the whole.

Certain metabolic modulator research focuses on the treatment specifically of hyperlipidemia, which consists of elevated levels of fat in the blood - particularly HDL (the bad cholesterol). Of course, this also means that metabolic modulators will naturally increase the metabolic burn rate throughout the entire body, as they cannot specifically target one area. This is where the attraction to the fitness community started.

A drug that promotes rapid weight loss without the need for extensive cardio can (hopefully) lead them to a leaner body, increased athletic performance, and better bodybuilding competitiveness.

As mentioned earlier, Cardarine is a banned substance by the WADA (world anti-doping agency) and cannot be used in any professional or Olympic sporting event. It also is not approved by the FDA and cannot be used for any public purpose. Below, we'll go over what the benefits and side effects of Cardarine GW-501516 are.

What are The Benefits and Side Effects of Cardarine GW-501516?

Cardarine works by increasing the energy expenditure in the cells and throughout the entire body, creating an unnaturally high metabolic burn rate, which aids in certain excess fat-related diseases and improper dieting lifestyles. Cardarine has several (purported) performance and health benefits, but it comes with certain risks and side effects:


  • Cardarine can be used as a treatment for obesity, as it helps to burn fat and weight quicker by substituting glucose cells for fatty acid cells.
  • Cardarine mimics the body's exercise routine and may give a boost to energy levels, enough to encourage patients' movement.
  • Cardarine is said to help or aid in the prevention of type 2 diabetes by improving blood glucose levels, even for those with low or no insulin production.
  • Cardarine also increases cardiac and cardiovascular metabolic rate, which burns excess fat in the blood levels - reducing the risk of heart and stroke disease.
  • Cardarine improves sports performance. In addition to a more leaner body, it increases energy, stamina, endurance, capacity, and strength.

It is worth noting that most of these clinical trials have been done in rodents, and are not at all conclusive in prolonged long-term use for humans. More research is necessary.


As with any unapproved drug, substance, or chemical, Cardarine has side effects purported by its use. More are being found every day as metabolic modulators continue to be studied. Common side effects include:

  • Because of the increased rate of energy use, causes cells to multiply quickly - increasing the chance of cancer-causing agents. The research that studied this also used a much larger dose than is recommended in certain human clinical trials.

Other major side effects have not yet been found due to lack of research, but other low-impact effects include:

  • Dizziness
  • Rapid heart rate and breathing
  • Nausea
  • Anxiety
  • Electrolyte imbalance
  • Increased appetite

Where Can I Find Cardarine?

Cardarine can be found at Pureraws. co. It is only available for sale on the condition that it is a research compound and can only be used for lab or research purposes. There are many disclaimers placed throughout the website, as well as further information on the composition of Cardarine, and what it is reported to achieve. It is necessary to follow these directions and use caution when purchasing this substance. Cardarine also cannot be taken on the advice of a medical professional, as it needs further research to view and record long-term effects.


Why was cardarine discontinued?

Cardarine was tested on animals, mostly mice and other rodents, and found to have extremely detrimental side effects, chief of which was the increase in carcinogenic material as well as cancer cells being present themselves. It is now being further researched after a few years of hiatus as a class of metabolic modulator drugs for its benefits for fat loss and a healthy cardiovascular system.

Is cardarine considered a SARM?

Selective Androgen Receptor Modulators (SARMs) are part of a substance that functions similar to anabolic steroids; they specifically target the androgenic receptors in the body and cause muscle and tissue to perform better and increase at an accelerated rate. Cardarine is a metabolic modulator, meaning that it specifically targets receptors that contribute to the metabolic burn rate, increasing the oxidation of fatty acids within the cells and burning through this energy.

What research has been done into cardarine?

The chief focus of research has been done on mice, for certain things such as weight loss, cardiac issues, obesity, and even endurance.

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