fbpx
Vegan Liftz is a community-supported website. We may earn a small commission on purchases made through our links. Learn more.

Turkesterone vs. Ecdysterone: What’s The Difference?

Jason Hughes
Published by Jason Hughes
Fact checked by Markus Oliver, BHSc FACT CHECKED
Last updated: April 20, 2022

Turkesterone and ecdysterone are two compounds that are often confused with one another. However, they are quite different. Let's take a closer look at the key differences between turkesterone vs. ecdysterone.

Turkesterone vs Ecdysterone

 

By constantly experimenting with Plant-Based ingredients, the supplement industry is finding new & useful compounds that can potentially create enhanced muscle building benefits, read on to understand how these new players stack up.

Many of these ingredients, such as Tribulus Terrestris and D-Aspartic Acid, have been used in pre-workout supplements for a long time so it should come a s no surprise that there will be new & often times useful Plant-Based compounds that can be extremely beneficial.

Turkesterone is a new ingredient that some people & scientists are stating, has the same power as anabolic steroids. To understand what this means we need to take a deeper dive into what these compounds are & how they affect our ability to build muscle, recover & have copious amounts of energy.

Is it all that it's hyped up to be?

Ecdysterone And Turkesterone

Many recent articles have discussed the benefits of Ecdysterone vs Turkesterone. This is a well-known fact. If you don't hear much about Ecdysterone and Turkesterone, let's talk about them now. They can help you gain muscle in a way you never thought possible.

Turkesterone: What Is It?

This plant's anabolic, adaptogenic, hepatoprotective, and hypoglycemic properties have made it a popular traditional medicine ingredient.

Throughout history, people in Uzbekistan and Tajikistan have looked forward to the plant's ability to build muscle and ease stomach pain. It also helps prevent heart disease.

Turkesterone is an anabolic compound found in plants, arthropods, and fungi. Turkesterone is an ecdysterone. It controls molting and metamorphosis in insects, and it may also play a role in the reproduction of these insects.

Turkesterone Supplement is a synthetic form of ecdysone.

In AML, the compound 20-hydroxyecdysone (ecdysterone) is the same as the one found in Ecdysterone, which is the same as Ecdysterone. Turkesterone and ecdysterone are very different.

Two of the main steroids found in Ajuga turkestanica are Turkesterone and ecdysterone, which make up 0.2–0.4% of the dry weight of the aerial parts.

YouTube player

Ecdysteroids

Ecdysteroids are steroid hormones that are found in insects, some aquatic animals, and plants. They play a big role in a lot of things that happen in insects' lives.

Even though ecdysteroids have a lot in common with testosterone, there is no evidence that they work the same way in humans.

People use ecdysteroids for a variety of reasons, including athletic performance, diabetes, and a lot of other things, but there isn't enough scientific evidence to back up these claims.

Ecdysterone for More Muscle & Strength

Ecdysterone (20-hydroxyecdysone) is a plant steroid. It is an ecdysteroid compound found in plants.

Previous human studies found that taking ecdysterone (12 mg/day for ten weeks) increased muscle and strength growth compared to taking a placebo.

How Does Ecdysterone Work?

Ecdysterone promotes lean mass gain by activating the estrogen receptor beta (ER).

This is important because ER signaling affects skeletal muscle growth and regeneration through satellite cell activation, stimulation of anabolic pathways, and changes in the immune system's ability to work.

Ecdysterone has been linked to increased muscle protein synthesis via direct or indirect stimulation of the PI3K/Akt signaling pathway.

It is important because it doesn't interact with the androgen receptor, so it doesn't cause suppression or any of the other problems that come with taking AAS.

Ecdysterone supplementation did not raise biomarkers that show liver or kidney toxicity in healthy people. This shows that ecdysterone is both effective and safe.

YouTube player

Turkesterone vs Ecdysterone: The Bottom Line

As with any supplement there are pros & cons to each and the results vary based off of each persons unique body chemistry. Erik our resident Lab-rat was more than eager to experiment with the top 3 rated Ecdysterone products. He tried each one (with the recommended dose) for an entire cycle or bottle whichever came first...to quote Erik "This $hit really works"!

Since Erik's initial thumbs-up response we have had all our trainers (men & women ) test the top three supplements using the same method and not changing their diet or their training. Without going into the study which will come out in depth in our Newsletter the verdict was 7 yay's and 3 nays. The supplement we found best for effectiveness, safety and quality Vegan ingredients was Nutriissa Ecdysterone you can purchase it here.

Ecdysterone is both effective and safe when taken orally with resistance training in healthy people who aren't already getting enough of it.

 

Similarities Of Turkesterone And Ecdysterone

They are Both Ecdysteroids

Ecdysteroids are steroid hormones that help animals molt and grow. They play a role in this process. People and plants like spinach and quinoa have ecdysteroids in them.

They are Both Not Anabolic-Androgenic Steroids

Turkesterone and ecdysterone are not anabolic-androgenic steroids, which means they don't bind to androgen receptors, which means they don't have side effects like liver toxicity.

Both Have Good Things About Them

These two hormones help people gain muscle and produce more protein.

The anabolic properties of both steroids must be studied further to determine which is superior. Not everyone agrees, and reactions to either compound may vary.

Turkesterone Is A Kind Of Ecdysterone

20-hydroxyecdysone (ecdysterone) is the source of turkesterone. It is a type of ecdysterone. They look very similar because they both have the same chemical structure.

Turkesterone: How can I buy it?

We have done exhaustive testing on Turkesterone, see our full write up here if you want to read the full story. After taking a bottle of Turkesterone the entire staff said "This stuff works", of course there were a couple of testers that had little to no effect whatsoever. With new supplements that are plant based, the exact science can still be a bit sketchy until more broad scientific studies can be conducted.

Final Thoughts

To summarize, turkesterone may have some beneficial effects on muscle growth and protein synthesis, but further research is necessary to confirm this. Ecdysterone has been studied in humans and shown to be effective and safe when taken orally. For these reasons, we recommend using a product that supplies 500mg of beta-ecdysterone per capsule as well as one that has the best manufacturing process on the market and that supplement is Gorilla Mind Turkesterone which you can purchase here.

References

1. Luan, F., Han, K., Li, M., Zhang, T., Liu, D., Yu, L., & Lv, H. (2019). Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Species from the Genus Ajuga L.: A Systematic Review. The American Journal of Chinese Medicine, 47(05), 959–1003. doi:10.1142/s0192415x19500502

2. Dinan L, Bourne P, Whiting P, et al. Synthesis and biological activities of turkesterone 11alpha-acyl derivatives. J Insect Sci. 2003;3:6. doi:10.1093/jis/3.1.6

3. Guibout, L., Mamadalieva, N., Balducci, C., Girault, J.-P., & Lafont, R. (2015). The minor ecdysteroids from Ajuga turkestanica. Phytochemical Analysis, 26(5), 293– 300.doi:10.1002/pca.2563

4. Mamadalieva NZ, El-Readi MZ, Ovidi E, Ashour ML, Hamoud R, Sagdullaev SS, Azimova SS, Tiezzi A, Wink M. 2013. Antiproliferative, antimicrobial and antioxidant activities of the chemical constituents of Ajuga turkestanica. Phytopharmacol 4(1): 1–18.

5. Syrov VN, Khushbaktova ZA, Tolubaev I, Eletskaya NV, Mamatkhanov AU. 1994. Effect of a lipid concentrate from the aboveground portion of Ajuga turkestanica on the metabolic processes and dynamics of healing skin wounds experimentally. Pharm Chem J 28(11): 837–840

6. Kutepova TA, Syrov VN, Khushbaktova ZA, Saatov Z. 2001. Hypoglycemic activity of the total ecdysteroid extract from Ajuga turkestanica. Pharm Chem J 35(11): 608–609.

7. Khalitova YD, Syrov VN, Akhmedkhodjaeva KhS, Mamatkhanov AU. 1998. Possible use of the extract of Ajuga turkestanica as a remedy contributing to lactation. Dokl Akad Nauk Respubliki Uzbekistan 8: 35–38

8. Shakhmurov GA, Syrov VN, Khushbaktova ZA. 2010. Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice. Pharm Chem J 44(1): 7–9.

9. Dinan L. 2009. The Karlson lecture. Phytoecdysteroids: what use are they? Arch Insect Biochem Physiol 72: 126–141.

10. Mamatkhanov AU, Yakubova MR, Syrov VN. 1998. Isolation of turkesterone from the epigeal part of Ajuga turkestanica and its anabolic activity. Chem Nat Comds 34(2): 150–154

11. Zubeldia JM, Hernández-Santana A, Jiménez-del-Rio M, Pérez-López V, Pérez-Machin R, Garcia-Castellano JM. 2012. In vitro characterization of the efficacy and safety profile of a proprietary Ajuga turkestanica extract. Chin Med 3: 215–222

12. Syrov VN, Saatov Z, Sagdullaev ShSh, Mamatkhanov AU. 2001. Study of the structureactivity-anabolic activity relationship for phytoecdysteroids extracted from some plants of central Asia. Pharm Chem J 35(12): 667–671.

13.Arthur ST, Zwetsloot KA, Lawrence MM, Nieman DC, Lila MA, Grace MH, Howden R, Cooley ID, Tkach JF, Keith MD, Demick JL, Blanton SE, Greiner RS, Bradley AM, Davenport ME, Badmaev V, Shanely RA. Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle. Eur Rev Med Pharmacol Sci. 2014;18(17):2584-92. PMID: 25268108.

14. J. Zubeldia, A. Hernández-Santana, M. Jiménez-del-Rio, V. Pérez-López, R. PérezMachín and J. García-Castellano, "In Vitro Characterization of the Efficacy and Safety Profile of a Proprietary Ajuga Turkestanica Extract," Chinese Medicine, Vol. 3 No. 4, 2012, pp. 215-222. doi: 10.4236/cm.2012.34031.

15. Syrov, V. N. (2000). Comparative experimental investigation of the anabolic activity of phytoecdysteroids and steranabols. Pharmaceutical Chemistry Journal, 34(4), 193– 197.doi:10.1007/bf02524596

16. Isenmann, E., Ambrosio, G., Joseph, J. F., Mazzarino, M., de la Torre, X., Zimmer, P., Parr, M. K. (2019). Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans. Archives of Toxicology, 93(7), 1807–1816.doi:10.1007/s00204-019-02490-x

17. Parr MK, Zhao P, Haupt O, Ngueu ST, Hengevoss J, Fritzemeier KH, Piechotta M, Schlörer N, Muhn P, Zheng WY, Xie MY, Diel P. Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone. Mol Nutr Food Res. 2014;58:1861–1872

18. Gorelick-Feldman, J.. “Phytoecdysteroids: understanding their anabolic activity.” (2009). DOI:10.7282/T3WQ041H

19. Gorelick-Feldman J, et al. Phytoecdysteroids increase protein synthesis in skeletal muscle cells. J Agric Food Chem. (2008)

20. Velders, M., Schleipen, B., Fritzemeier, K. H., Zierau, O., & Diel, P. (2012). Selective estrogen receptor-beta activation stimulates skeletal muscle growth and regeneration. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 26(5), 1909–1920. https://doi.org/10.1096/fj.11-194779

21. Lafont R, Dinan L. Practical uses for ecdysteroids in mammals including humans: an update. J Insect Sci. 2003;3:7. doi:10.1093/jis/3.1.7

22.https://pubmed.ncbi.nlm.nih.gov/31123801/

23.https://examine.com/supplements/ecdysteroids/research/

24.https://www.frontiersin.org/articles/10.3389/fphar.2020.561537/full

 

 


About the author