Losing Weight With the Power of Peptides

Now that we know more about the basics of peptides, we know that certain peptides serve specific functions. If you’re looking for the best peptides for weight loss, here’s a comprehensive list.

Tesamorelin

Tesamorelin is a hormone peptide for weight loss, traditionally for HIV patients. This specific peptide hasn’t had much use for other forms of weight loss, but it could still be beneficial. A doctor’s prescription is necessary for this drug.

Mimicking a peptide that naturally comes from the hypothalamus gland of the brain, tesamorelin targets abdomen fat and significantly increases lipid metabolism.

It’s necessary to deal with an injection under the skin to take this drug. The injections are usually self-administered into the abdomen under the belly button. You only usually need one injection daily, around the same time every day.

If you have tesamorelin, you’ll have to mix a powder with a solution to create your injections. Don’t worry, as your doctor will thoroughly explain the process and show you how to do this.

There can be some minor side effects to tesamorelin, ranging from things like swelling of the hands, joint pain, or even vomiting. Occasionally, severe side effects can occur, like hives or shortness of breath.

Overall, tesamorelin is particularly effective at combating extra fat in the stomach and can be an ideal option if you’re looking to size down this area.

Ipamorelin

Next, ipamorelin is a peptide that relates to growth hormones. This drug helps to stimulate the pituitary gland into releasing growth hormones, which typically decrease as we age.

Growth hormones are present in children in large quantities, but adults tend to have fewer. These hormones help build lean muscle, reduce body fat, improve sleep, increase energy, and support healthy skin.

Similar to the previous peptide, ipamorelin must be through injection. Usually, you inject yourself in the abdomen or other fatty parts of the body, so it goes under the skin.

Depending on what your doctor prescribes, you can have either one to three injections daily. Ipamorelin is a peptide for weight loss that can take some time, up to three to six months, for the full extent of the drug’s impacts.

This drug typically comes in a vial, ready to go. An increase in hunger and dry mouth are the most common side effects, while severe effects like hives, drowsiness, and vomiting are rare.

Tesofensine

Tesofensine is a peptide drug still in clinical trials but could revolutionize treatments for losing weight. This peptide works differently than others because instead of just mimicking a naturally occurring hormone, it also helps prevent the body from absorbing certain hormones.

It works in multiple phases. First, tesofensine interacts with the serotonin and dopamine centers of the brain to reduce appetite. The drug helps ensure you feel satisfied with less food for longer.

Next, the drug works against fat by increasing the body’s ability to break down fat and reducing fatty tissue. Some studies have seen a 4 to 10 percent reduction in body weight after taking this drug, which is a significant change.

One main concern is the effect on the heart, as a common side effect has been an increase in heart rate. Otherwise, the patients in these studies have mostly only had diarrhea, constipation, or dry mouth.

So far, it seems that tesofensine would be another injection. Unfortunately, it is still in phase III clinical trials, but we may soon see this drug coming to pharmacies around the US.

CJC-1295

CJC-1295 is another peptide that increases the body’s ability to produce growth hormones, and it commonly works hand in hand with ipamorelin. Similarly, it interacts with the pituitary gland to encourage growth hormones to release into the body.

It doesn’t stimulate the appetite, making it an ideal peptide for weight loss. It can increase muscle growth, bone density, immune function, cognition, memory, cellular repair, collagen production, and fat loss. That’s quite a lot for a single drug!

When taken with ipamorelin, CJC-1295 can create drastic results by significantly impacting growth hormones. The side effects of this peptide range from headache, diarrhea, and abdominal pain.

If you plan to take the peptide for a long time, you’ll have to do hormone breaks every three to six months to allow your pituitary gland to recover.

MOTS-C

Now we have a peptide known as MOTS-c, which can mimic exercise in the body. Overall, it works to regulate your metabolism and can have multiple effects.

First, it has promising signs that it can help regulate glucose and insulin levels in the body, even for people with diabetes. It does this by interacting with skeletal muscle, similar to exercise.

This peptide for weight loss can also help regulate metabolisms, especially if you have a metabolism issue. MOTS-c impacts metabolic flexibility, which is the body’s ability to adapt to receiving different amounts of food each day.

Together, it increases metabolic activity, weight loss, and exercise capacity and even protects against osteoporosis.

Research for MOTS-c is still underway, but it has a promising chance to help fight weight issues and diabetes.

Glycyrrhetinic Acid

Finally, glycyrrhetinic acid is a peptide quite different from the others. This peptide is found naturally at the root of licorice plants, and it’s commonly an alternative sweetener.

That might seem counterintuitive, but glycyrrhetinic acid has a long history in herbal medicine practices. It’s well-known for its immunity-boosting, anti-inflammatory, and antiviral functions.

It’s typically a topical treatment, and some studies show that this peptide can help reduce fat in specific areas. When applying the cream to a fatty area like the thighs, it can block the function of fat cells and reduce the outer layers of fat tissue.

Scientists are focusing on the other effects of glycyrrhetinic acid, but that could soon change.